ABSTRACT
This study was aimed at evaluating the changes in the antibody titers and neutralization ability before and after inoculation with an mRNA COVID-19 vaccine (Pfizer, USA) among healthcare professionals (HCPs) in Japan. A total of 221 HCPs were enrolled and their blood samples were collected at three time points: (1) before vaccination, (2) 3 weeks after the first dose, and (3) 3 weeks after the second dose. The titers of anti-SARS-CoV-2 Spike protein IgG antibody were measured in all the samples using VITROS-Anti-SARS-CoV-2 S1 Quant IgG Antibody (CLEIA, Ortho-Clinical Diagnostics, Inc.), and the surrogate Virus Neutralization Test (sVNT) (ELISA, GenScript, USA) was performed in the samples obtained after the vaccination. The anti-SARS-CoV-2 IgG titers were (1) median: 0.16;Interquartile (IQR): 0.10-0.27, (2) median: 250;IQR: 99.5-466 and (3) median: 2,400;IQR: 1,480-3,950, respectively, at the three time-points. Our study also revealed the relationship between the anti-SARS-CoV-2 IgG antibody titer and the antibody neutralization activity.
ABSTRACT
The "Coronavirus disease 2019" has resulted by infecting millions of people globally and indirectly affect the individuals through disruption of daily routine. Since the diagnosis of index case, linked to sea food and wet animal wholesale market in Wuhan, China, in December 2019.The discharge of this virus has spread worldwide and has threatened the whole world and considered as pandemic recently. World Health Organization (WHO] has declared COVID-19 Pandemic on March 2020. Long term health outcomes of COVID-19 have been reported with the similar diseases from other coronaviruses. "Middle East Respiratory Syndrome" and "Severe Acute Respiratory Syndrome". Major adverse outcomes was found to affect different body systems in humans (neurological system, GIT, hepatic an renal system, CVS, muscle pain, mental health outcomes, pulmonary outcomes, fungal infection and many more chronic symptoms were observed in patients in Post-COVID-19 recovery. Globally the community is focusing on trialing COVID-19 vaccines and its treatment, and its equally important to focus on recovered patients an possible events faced by patients in post recovery period. Thus this article emphasizes long-term COVID-19 health complications in patients during Post recovery period.
ABSTRACT
The worldwide medical systems are still being severely impacted by the coronavirus disease-2019 (COVID-19) pandemic, which is responsible for catastrophic mortality and morbidity. It becomes more and more obvious that this unique respiratory virus's impacts go beyond the respiratory system as time goes on and our comprehension of it deepens. The transmembrane serine protease 2 (TMPRSS2) protein is necessary for the severe acute respiratory syndrome coronavirus 2, which is the cause of COVID-19, to gain cellular entry through the angiotensin-converting enzyme 2 (ACE2) receptor. Most endocrine glands exhibit high levels of expression for ACE2 and TMPRSS2. This pays the attention to the effect of COVID-19 on the endocrine system. Besides its capability to pass to the central nervous system especially the hypothalamus inducing a lot of functional disorders in COVID-19 individuals. Although effective vaccines became widely available, and mortality declined but attention is shifting more and more to the lengthy health impacts on COVID-19 survivors. To inform suitable research and effective management, this review provides an overview of the data examining the impacts of COVID-19 on the endocrine glands besides the hypothalamus. In addition, we reported if the endocrinal and thalamic disorders could affect the incidence and progress of COVID-19. Copyright© by the Egyptian Association of Immunologists.
ABSTRACT
Microsponges are extremely cross-linked, non-collapsible, porous, polymeric microspheres having particle size range from 5 to 300 mum. They are highly effective, stable, non-irritant, nontoxic, non-allergic, non-mutagenic and also minimum side effects with improved patient compliance. Ivermectin is act as an antiparasitic agent and antiviral agent, shows an inhibitory effect on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in primary stage. Ivermectin microsponges is prepared by quasi emulsion-solvent diffusion method by using two polymers in different proportion. Determination of entrapment efficiency and production yield was done for trail batches. Characterization of formulation done by SEM,PXRD and FTIR. Copyright © 2022 Wolters Kluwer Medknow Publications. All rights reserved.